Relevant Developments in the Use of Three‐Component Reactions for the Total Synthesis of Natural Products. The last 15 Years

Author:

Larghi Enrique L.1ORCID,Bracca Andrea B. J.1ORCID,Simonetti Sebastian O.1ORCID,Kaufman Teodoro S.1ORCID

Affiliation:

1. Instituto de Química Rosario IQUIR (CONICET-UNR) Facultad de Ciencias Bioquímicas y Farmacéuticas Universidad Nacional de Rosario (UNR) Suipacha 531 2000 Rosario Argentina

Abstract

AbstractMulticomponent reactions (MCRs) offer a highly useful and valuable strategy that can fulfill an important role in synthesizing complex polysubstituted compounds, by simplifying otherwise long sequences and increasing their efficiency. The total synthesis of selected natural products employing three‐component reactions as their common strategic MCR approach, is reviewed on a case‐by‐case basis with selected targets conquered during the last 15 years. The revision includes detailed descriptions of the selected successful sequences; relevant information on the isolation, and bioactivity of the different natural targets is also briefly provided.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Wiley

Reference237 articles.

1. Multicomponent Reactions in Organic Synthesis. Eds: J. Zhu Q. Wang M.-X. Wang; Wiley New York 2015.

2.  

3. Natural Product Synthesis Using Multicomponent Reaction Strategies

4. Application of multicomponent reactions in the total synthesis of natural peptides

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