A regio- and stereocontrolled approach to the synthesis of 4-CF3-substituted spiro[chromeno[3,4-c]pyrrolidine-oxindoles]viareversible [3+2] cycloaddition of azomethine ylides generated from isatins and sarcosine to 3-nitro-2-(trifluoromethyl)-2H-chromenes-Reference-Cited by-同舟云学术

A regio- and stereocontrolled approach to the synthesis of 4-CF3-substituted spiro[chromeno[3,4-c]pyrrolidine-oxindoles]viareversible [3+2] cycloaddition of azomethine ylides generated from isatins and sarcosine to 3-nitro-2-(trifluoromethyl)-2H-chromenes

Published:2019 Issue:47 Volume:43 Page:18495-18504
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Kutyashev Igor B.¹²³⁴,Ulitko Maria V.¹²³⁴^ORCID,Barkov Alexey Yu.¹²³⁴^ORCID,Zimnitskiy Nikolay S.¹²³⁴^ORCID,Korotaev Vladislav Yu.¹²³⁴^ORCID,Sosnovskikh Vyacheslav Ya.¹²³⁴^ORCID

Affiliation:

1. Institute of Natural Sciences and Mathematics

2. Ural Federal University

3. Ekaterinburg

4. Russian Federation

Abstract

The first example of regio- and stereocontrolled synthesis of 4-CF₃-spiro[chromeno[3,4-c]pyrrolidine-oxindoles] with anticancer activity.

Funder

Russian Foundation for Basic Research

Ministry of Education and Science of the Russian Federation

Publisher

Royal Society of Chemistry (RSC)