Synthesis and analysis of the anticancer activity of platinum(ii) complexes incorporating dipyridoquinoxaline variants

Author:

Pages Benjamin J.12342,Li Feng12342,Wormell Paul425,Ang Dale L.12342,Clegg Jack K.678,Kepert Cameron J.91011,Spare Lawson K.12342,Danchaiwijit Supawich12342,Aldrich-Wright Janice R.12342

Affiliation:

1. Nanoscale Organisation and Dynamics Group

2. University of Western Sydney

3. Penrith South DC, Australia

4. School of Science and Health

5. Penrith, Australia

6. School of Chemistry and Molecular Biosciences

7. The University of Queensland

8. St Lucia, Australia

9. School of Chemistry

10. The University of Sydney

11. , Australia

Abstract

Platinum complexes incorporating variants of dpq were synthesised. Their DNA affinity and cytotoxicity were compared to complexes containing phen variants, revealing unexpected trends in biological activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference53 articles.

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3. B. H. Harper , F.Li , R.Beard , K. B.Garbutcheon-Singh , N. S.Ng and J. R.Aldrich-Wright , in Supramolecular Systems in Biomedical Fields , ed. H. J. Schneider , Royal Society of Chemistry , Cambridge, UK , 1st edn, 2013 , ch. 9

4. Mechanisms of resistance to cisplatin

5. The status of platinum anticancer drugs in the clinic and in clinical trials

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