Iridium(<scp>iii</scp>)-based minor groove binding complexes as DNA photocleavage agents-Reference-Cited by-同舟云学术

Iridium(iii)-based minor groove binding complexes as DNA photocleavage agents

Published:2024 Issue:17 Volume:53 Page:7282-7291
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Aderinto Stephen O.¹,John Torsten²^ORCID,Onawole Abdulmujeeb³,Galleh Raphael Peter⁴,Thomas Jim A.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK

2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

3. Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia

4. School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK

Abstract

Transition metal complexes containing the qtpy ligand with high-energy excited states are reported. Binding studies with duplex and quadruplex DNA showed a preference for the Ir(iii) complexes as groove binders to DNA structures.

Funder

University of Sheffield

Alexander von Humboldt-Stiftung

Office of Naval Research

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00171K

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