Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu2Mg in toluene-Reference-Cited by-同舟云学术

Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu2Mg in toluene

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hess Andreas¹²³⁴,Prohaska Jan P.¹²³⁴,Doerrich Sabrina B.¹²³⁴,Trauner Florian¹²³⁴,Lutter Ferdinand H.¹²³⁴,Lemaire Sébastien⁵⁶⁷⁸,Wagschal Simon⁵⁶⁹¹⁰^ORCID,Karaghiosoff Konstantin¹²³⁴,Knochel Paul¹²³⁴^ORCID

Affiliation:

1. Ludwig-Maximilians-Universität München

2. Department Chemie

3. 81377 München

4. Germany

5. Janssen Pharmaceutica

6. Chemical Process Research & Development

7. B-2340 Beerse

8. Belgium

9. 8200 Schaffhausen

10. Switzerland

Abstract

A toluene solution of sBu₂Mg allowed a regioselective ortho-magnesiation of aromatic and heterocyclic systems. A second ortho,ortho′-functionalization was achieved in the case of aryl oxazolines, N-aryl pyrazoles as well as N-aryl triazoles.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01777B

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