Calculation-assisted regioselective functionalization of the imidazo[1,2-<i>a</i>]pyrazine scaffold <i>via</i> zinc and magnesium organometallic intermediates-Reference-Cited by-同舟云学术

Calculation-assisted regioselective functionalization of the imidazo[1,2-a]pyrazine scaffold via zinc and magnesium organometallic intermediates

Published:2023 Issue:40 Volume:14 Page:11261-11266
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kastrati Agonist¹^ORCID,Kremsmair Alexander¹,Sunagatullina Alisa S.¹,Korotenko Vasilii¹^ORCID,Guersoy Yusuf C.¹,Rout Saroj K.¹,Lima Fabio²,Brocklehurst Cara E.²^ORCID,Karaghiosoff Konstantin¹^ORCID,Zipse Hendrik¹^ORCID,Knochel Paul¹^ORCID

Affiliation:

1. Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377 München, Germany

2. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 4057 Basel, Switzerland

Abstract

Theoretical calculations, such as pKa-determinations, enabled the design of methods for the selective functionalization of the underexplored 6-chloroimidazo[1,2-a]pyrazine using readily available TMP-bases and organometallic reagents.

Funder

Deutsche Forschungsgemeinschaft

Ludwig-Maximilians-Universität München

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02893C

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