Development of a solid-compatible continuous flow reactor for the paraformaldehyde slurry mediated α-hydroxymethylation of methyl vinyl ketone-Reference-Cited by-同舟云学术

Development of a solid-compatible continuous flow reactor for the paraformaldehyde slurry mediated α-hydroxymethylation of methyl vinyl ketone

Published:2024 Issue:8 Volume:9 Page:2240-2248
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Vandekerckhove Bavo¹,Van Coillie Lise¹,Metten Bert²^ORCID,Heugebaert Thomas S. A.¹^ORCID,Stevens Christian V.¹^ORCID

Affiliation:

1. SynBioC Research Group, Department of Sustainable Organic Chemistry and Technology, Department of Green Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium

2. Ajinomoto Bio-Pharma Services, Cooppallaan 91, 9230 Wetteren, Belgium

Abstract

α-Hydroxymethylation reactions often entail safety precautions concerning formaldehyde gas. A paraformaldehyde slurry within a solid-compatible continuous flow setup can now be used with a reduced reaction time and increased productivity.

Funder

Agentschap Innoveren en Ondernemen

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RE/D4RE00220B

Reference39 articles.

1. Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines

2. Synthesis, in vitro, and in vivo evaluation of novel functionalized quaternary ammonium curcuminoids as potential anti-cancer agents

3. Microwave-assisted synthesis of hydroxymethyl ketones using azolium-2-carboxylate zwitterions as catalyst precursors

4. Biocatalytic Strategies for the Asymmetric Synthesis of α-Hydroxy Ketones

5. Drug/Lead Compound Hydroxymethylation as a Simple Approach to Enhance Pharmacodynamic and Pharmacokinetic Properties