Proline-rich antimicrobial peptides targeting protein synthesis-Reference-Cited by-同舟云学术

Proline-rich antimicrobial peptides targeting protein synthesis

Published:2017 Issue:7 Volume:34 Page:702-711
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Graf Michael¹²³⁴⁵^ORCID,Mardirossian Mario¹²³⁴⁵,Nguyen Fabian¹²³⁴⁵,Seefeldt A. Carolin⁶⁷⁸⁹¹⁰,Guichard Gilles¹¹¹²¹³¹⁴¹⁵,Scocchi Marco¹⁶¹⁷¹⁸¹⁹,Innis C. Axel⁶⁷⁸⁹¹⁰^ORCID,Wilson Daniel N.¹²³⁴⁵^ORCID

Affiliation:

1. Gene Center

2. Department for Biochemistry and Center for Integrated Protein Sciences Munich (CiPS-M)

3. University of Munich

4. 81377 Munich

5. Germany

6. Univ. Bordeaux

7. ARNA Laboratory

8. Inserm U1212

9. CNRS UMR 5320

10. IECB

11. Université de Bordeaux

12. CNRS

13. Institut Polytechnique de Bordeaux

14. UMR 5248

15. Institut de Chimie et Biologie des Membranes et des Nano-objets (CBMN)

16. Department of Life Sciences

17. University of Trieste

18. Trieste

19. Italy

Abstract

Proline-rich antimicrobial peptides (PrAMPs) bind within the exit tunnel of the ribosome and inhibit translation elongation. Structures of ribosome-bound PrAMPs reveal the interactions with ribosomal components and could pave the way for the development of novel peptide-based antimicrobial agents.

Funder

Agence Nationale de la Recherche

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NP/C7NP00020K

Reference62 articles.

1. Antimicrobial Peptides in Health and Disease

2. Peptide Antimicrobial Agents