An efficient one-pot approach for the regio- and diastereoselective synthesis of trans-dihydrofuran derivatives: cytotoxicity and DNA-binding studies

Author:

Tangella Yellaiah12345,Manasa Kesari Lakshmi12346,Laxma Nayak V.1234,Sathish Manda1234,Sridhar B.7284,Alarifi Abdullah910111213,Nagesh Narayana1434ORCID,Kamal Ahmed12345ORCID

Affiliation:

1. Medicinal Chemistry and Biotechnology

2. CSIR-Indian Institute of Chemical Technology

3. Hyderabad 500 007

4. India

5. Academy of Scientific and Innovative Research

6. Department of Medicinal Chemistry

7. Centre for X-ray Crystallography

8. Hyderabad-500007

9. Catalytic Chemistry Research Chair

10. Chemistry Department

11. College of Science

12. King Saud University

13. Riyadh 11451

14. CSIR-Centre for Cellular and Molecular Biology

Abstract

A facile one-pot, three component strategy has been developed for the construction oftrans-2,3-dihydrofuran derivatives. All the synthesized compounds have been evaluated for their cytotoxic activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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