In vivo evaluation of compliance mismatch on intimal hyperplasia formation in small diameter vascular grafts

Author:

Yao Yuan1ORCID,Pohan Grace1,Cutiongco Marie F. A.23ORCID,Jeong YeJin1ORCID,Kunihiro Joshua1ORCID,Zaw Aung Moe1,David Dency1,Shangguan Hanyue456,Yu Alfred C. H.456ORCID,Yim Evelyn K. F.1256ORCID

Affiliation:

1. Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1

2. Mechanobiology Institute, National University of Singapore, 9 Engineering Drive 1, Singapore 117575

3. Division of Cell Matrix Biology and Regenerative Medicine, The University of Manchester, Oxford Road, Manchester, UK M13 9PL

4. Schlegel Research Institute for Aging, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1

5. Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1

6. Center for Biotechnology and Bioengineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1

Abstract

Synthetic vascular grafts with varied compliance were fabricated and studied in vivo. Reducing compliance mismatch between graft and native artery lowered intimal hyperplasia formation and increased graft patency.

Funder

National Institutes of Health

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

National Medical Research Council

Agency for Science, Technology and Research

National Research Foundation Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Reference55 articles.

1. W. H. Organization , Cardiovascular diseases (CVDs), https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)

2. Development of Small-Diameter Vascular Grafts

3. ePTFE functionalization for medical applications

4. The Tissue-Engineered Vascular Graft—Past, Present, and Future

5. The daunting quest for a small diameter vascular graft

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Recent Progress in Strain-Engineered Stretchable Constructs;International Journal of Precision Engineering and Manufacturing-Green Technology;2023-09-26

2. Recent Progress in Strain-Engineered Stretchable Constructs;INT J PR ENG MAN-GT;2023

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