Electrically sensing Hachimoji DNA nucleotides through a hybrid graphene/h-BN nanopore

Author:

de Souza Fábio A. L.1234ORCID,Sivaraman Ganesh56789ORCID,Fyta Maria10111213ORCID,Scheicher Ralph H.14151617ORCID,Scopel Wanderlã L.1819204ORCID,Amorim Rodrigo G.182122234ORCID

Affiliation:

1. Federal Institute of Education

2. Science and Technology of Espírito Santo

3. Ibatiba/ES

4. Brazil

5. Argonne Leadership Computing Facility

6. Argonne National Laboratory

7. Lemont

8. USA

9. Data Science and Learning Division

10. Institute for Computational Physics

11. Universität Stuttgart

12. Stuttgart

13. Germany

14. Division of Materials Theory

15. Department of Physics and Astronomy

16. Uppsala University

17. Sweden

18. Departamento de Física

19. Universidade Federal do Espírito Santo-UFES

20. Vitória/ES

21. ICEx

22. Universidade Federal Fluminense – UFF

23. Volta Redonda/RJ

Abstract

We show that synthetic Hachimoji nucleobases can be reliably sensed by analysing the strength and duration of characteristic electrical signals generated when their presence in a nanopore modulates the conductance of an adjacent carbon wire.

Funder

Argonne National Laboratory

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Estadual de Amparo à Pesquisa do Estado do Espírito Santo

Deutsche Forschungsgemeinschaft

Universität Stuttgart

Vetenskapsrådet

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Reference46 articles.

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2. Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

3. A semi-synthetic organism with an expanded genetic alphabet

4. Hachimoji DNA and RNA: A genetic system with eight building blocks

5. D. Branton , D. W.Deamer , A.Marziali , H.Bayley , S. A.Benner , T.Butler , M.Di Ventra , S.Garaj , A.Hibbs and X.Huang , et al. , Nanoscience and technology: A Collection of Reviews from Nature Journals , World Scientific , 2010 , pp. 261–268

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