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A semi-synthetic organism with an expanded genetic alphabet

Published:2014-05 Issue:7500 Volume:509 Page:385-388
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Malyshev Denis A.,Dhami Kirandeep,Lavergne Thomas,Chen Tingjian,Dai Nan,Foster Jeremy M.,Corrêa Ivan R.,Romesberg Floyd E.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature13314.pdf

Reference38 articles.

1. Malyshev, D. A. et al. Efficient and sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet. Proc. Natl Acad. Sci. USA 109, 12005–12010 (2012)

2. Yang, Z., Chen, F., Alvarado, J. B. & Benner, S. A. Amplification, mutation, and sequencing of a six-letter synthetic genetic system. J. Am. Chem. Soc. 133, 15105–15112 (2011)

3. Yamashige, R. et al. Highly specific unnatural base pair systems as a third base pair for PCR amplification. Nucleic Acids Res. 40, 2793–2806 (2012)

4. Seo, Y. J., Malyshev, D. A., Lavergne, T., Ordoukhanian, P. & Romesberg, F. E. Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs. J. Am. Chem. Soc. 133, 19878–19888 (2011)

5. Seo, Y. J., Matsuda, S. & Romesberg, F. E. Transcription of an expanded genetic alphabet. J. Am. Chem. Soc. 131, 5046–5047 (2009)

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