Novel quinoline-piperazine hybrids: the design, synthesis and evaluation of antibacterial and antituberculosis properties

Author:

Gnanavelu Karunanidhi12,K. S. Vinay Kumar1,Eswaran Sumesh1ORCID,Sivashanmugam Karthikeyan2

Affiliation:

1. Anthem Biosciences Pvt. Ltd., #49, Bommasandra Industrial Area, Bommasandra, Bangalore 560099, Karnataka, India

2. School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India

Abstract

We synthesised a series of 2,4,6-substituted quinoline conjugated piperazine coupled sulfonamides and amides and evaluated their in vitro antibacterial activity against susceptible and resistant Gram-positive and Gram-negative bacteria.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Quinolone Molecular Structure‐Activity Relationships: What We Have Learned about Improving Antimicrobial Activity

2. World Health Organization , Global tuberculosis report 2019 , 2019

3. O. N.Jim , Tackling drug-resistant infections globally: final report and recommendations , Government of the United Kingdom , 2016

4. World Health Organization , Global antimicrobial resistance and use surveillance system (GLASS) report: 2021 , Report 9240027335, 2021

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