Design, Synthesis and Characterization of Novel 1H-1,2,3-Triazole Quinoline-Isatin Tethered Conjugates-Reference-Cited by-同舟云学术

Design, Synthesis and Characterization of Novel 1H-1,2,3-Triazole Quinoline-Isatin Tethered Conjugates

Published:2023 Issue:5 Volume:35 Page:1269-1275
ISSN:0975-427X
Container-title:Asian Journal of Chemistry
language:en
Short-container-title:Asian J. Chem.

Author:

Kant Ravi¹^ORCID,Saini Keshav Kumar²^ORCID,Upadhyay Ravindra Kumar³^ORCID,Amri Nasser⁴,Kumar Rakesh⁵^ORCID,Kumar Lalita S.⁶^ORCID

Affiliation:

1. 1Chemistry Discipline, School of Sciences, Indira Gandhi National Open University, New Delhi-110068, India 2Department of Chemistry, Government Post Graduate College, Noida-201301, India

2. 3Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi-110003, India 4Department of Chemistry, University of Delhi, Delhi-110007, India

3. 4Department of Chemistry, University of Delhi, Delhi-110007, India 5Department of chemistry, Sri Venkateswara College, University of Delhi, Dhaula Kuan, New Delhi-110021, India

4. Department of Chemistry, Faculty of Science, Jazan University, P.O. Box 2097, Jazan 45142, Saudi Arabia

5. Department of Chemistry, University of Delhi, Delhi-110007, India

6. Chemistry Discipline, School of Sciences, Indira Gandhi National Open University, New Delhi-110068, India

Abstract

Quinoline is an important heterocyclic scaffold which is found in a variety of natural compounds (cinchona alkaloids) and therapeutically active drugs with various biological functions. Because of its varied chemical and pharmacological characteristics, quinoline and its derivatives have long drawn the attention of both synthetic and biological chemists. A newer class of quinoline-isatin tethered 1,2,3-triazole conjugates was synthesized in this context, using copper-promoted click chemistry with various organic systems. Ten derivatives of 1,2,3-triazole-tethered 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline derivatives of isatin were synthesized and well characterized by using analytical techniques such as mass spectrometry, IR, 1H NMR and 13C NMR spectroscopy.

Publisher

Asian Journal of Chemistry

Subject

General Chemistry

Reference32 articles.

1. Novel quinoline-piperazine hybrids: the design, synthesis and evaluation of antibacterial and antituberculosis properties

2. Synthesis and antimicrobial activities of novel quinoline derivatives carrying 1,2,4-triazole moiety

3. Quinolone Molecular Structure‐Activity Relationships: What We Have Learned about Improving Antimicrobial Activity

4. Synthesis and antimicrobial activity evaluation of indole-azole-fluoroquinolone hybrids with highly functionalized functional groups

5. Novel hybrid molecules based on triazole-quinoline as potential anticancer agents: screening on MCF-7 cell line, docking studies, and pharmacokinetics evaluation