Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: synthesis and biological evaluation
Author:
Affiliation:
1. Drug Development Core
2. Faculty of Health Sciences
3. University of Macau
4. Taipa
5. China
6. Department of Biology
7. Southern University of Science and Technology
8. Shenzhen
Abstract
The synthesis and biological assays were described herein to firstly identify a novel PDK1 inhibitor.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA14060B
Reference21 articles.
1. Targeting metabolic transformation for cancer therapy
2. Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation
3. The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
4. A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
5. Metabolic Modulation of Glioblastoma with Dichloroacetate
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