Metabolic Modulation of Glioblastoma with Dichloroacetate-Reference-Cited by-同舟云学术

Metabolic Modulation of Glioblastoma with Dichloroacetate

Published:2010-05-12 Issue:31 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Michelakis E. D.¹,Sutendra G.¹,Dromparis P.¹,Webster L.¹,Haromy A.¹,Niven E.²,Maguire C.²,Gammer T.-L.¹,Mackey J. R.³,Fulton D.³,Abdulkarim B.³,McMurtry M. S.¹,Petruk K. C.⁴

Affiliation:

1. Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

2. Department of Biomedical Engineering and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

3. Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

4. Department of Neurosurgery, University of Alberta, Edmonton, Alberta, Canada T6G 2B7.

Abstract

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, shifts metabolism away from aerobic glycolysis in glioblastoma tumor cells and may have clinical efficacy in patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Malignant Gliomas in Adults

2. A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

3. A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

4. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

5. The pharmacology of dichloroacetate

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