Assessment of the gastrointestinal fate of bacterial nanocellulose and its toxicological effects after repeated-dose oral administration

Author:

Rodrigues Ana Cristina12,Costa Lígia12,Silva-Carvalho Ricardo12ORCID,Mota Renato12,Duarte-Silva Sara34,Teixeira-Castro Andreia34,Lamas Nuno345,Oliveira Gonçalo N. P.6ORCID,Wan Yizao78,Dourado Fernando12,Gama Miguel12ORCID

Affiliation:

1. CEB – Centre of Biological Engineering, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal

2. LABBELS – Associate Laboratory, Braga, Guimarães, Portugal

3. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal

4. ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal

5. Anatomic Pathology Service, Pathology Department, Centro Hospitalar e Universitário do Porto, Largo Professor Abel Salazar, 4099-001, Porto, Portugal

6. IFIMUP – Instituto de Física de Materiais Avançados, Nanotecnologia e Fotónica, Departamento de Física e Astronomia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007, Porto, Portugal

7. Jiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang, China

8. School of Materials Science and Engineering, Tianjin University, Tianjin, China

Abstract

The gastrointestinal fate of Bacterial NanoCellulose (BNC) was analysed, in particular attempting to clarify whether any absorption occurs. Novel insights assuring the safety of this material for food applications and human consumption are provided.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

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