Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening-Reference-Cited by-同舟云学术

Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening

Published:2015 Issue:5 Volume:11 Page:1305-1318
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Sindhu Thangaraj¹²³⁴⁵,Srinivasan Pappu¹²³⁴⁵

Affiliation:

1. Molecular Biology Lab

2. Department of Bioinformatics

3. Alagappa University

4. Karaikudi

5. India

Abstract

Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00137D

Reference35 articles.

1. Inflammation and the pathogenesis of diabetic nephropathy

2. Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

3. Bile acids: regulation of synthesis

4. Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

5. Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

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