Synthesis and identification of heteroaromaticN-benzyl sulfonamides as potential anticancer agents

Author:

Hopkins Megan D.1234,Abebe Felagot A.1234,Scott Kristina A.1234,Ozmer Garett L.1234,Sheir Alec A.1234,Schroeder Lucas J.1234,Sheaff Robert J.1234,Lamar Angus A.1234ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. The University of Tulsa

3. Tulsa

4. USA

Abstract

The regioselective incorporation of a sulfonamide unit to a broad range of heteroarene scaffolds has been developed. SynthesizedN-benzyl sulfonamides have been screened against a variety of cancer cell lines for cytotoxicity effects.

Funder

Oklahoma Center for the Advancement of Science and Technology

University of Tulsa

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference119 articles.

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3. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

4. Carboxylic Acid (Bio)Isosteres in Drug Design

5. Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

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