Synthesis and biological evaluation of <i>N</i>-alkyl sulfonamides derived from polycyclic hydrocarbon scaffolds using a nitrogen-centered radical approach-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of N-alkyl sulfonamides derived from polycyclic hydrocarbon scaffolds using a nitrogen-centered radical approach

Published:2022 Issue:33 Volume:20 Page:6680-6693
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hopkins Megan D.¹,Witt Ryan C.¹,Flusche Ann Marie E.¹,Philo John E.¹,Ozmer Garett L.¹,Purser Gordon H.¹,Sheaff Robert J.¹,Lamar Angus A.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The University of Tulsa, 800 South Tucker Drive, Tulsa, Oklahoma, 74104, USA

Abstract

New methods for installation of a N-sulfonyl unit into PH scaffolds via a N-centered radical approach have been developed. Synthesized PH sulfonamides have been screened against mammalian cell lines and bacterial strains for biological activity.

Funder

University of Tulsa

Oklahoma Center for the Advancement of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01291J

Reference78 articles.

1. The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

2. Pharmaceuticals that contain polycyclic hydrocarbon scaffolds

3. Adamantane – A Lead Structure for Drugs in Clinical Practice

4. Pharmacological profile of natural and synthetic compounds with rigid adamantane-based scaffolds as potential agents for the treatment of neurodegenerative diseases

5. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

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