Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties-Reference-Cited by-同舟云学术

Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties

Published:2021 Issue:2 Volume:12 Page:254-262
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Federico Stephanie¹²³⁴^ORCID,Margiotta Enrico⁵⁶⁷⁸⁴,Moro Stefano⁵⁶⁷⁸⁴^ORCID,Kachler Sonja⁹¹⁰¹¹¹²,Klotz Karl-Norbert⁹¹⁰¹¹¹²,Spalluto Giampiero¹²³⁴

Affiliation:

1. Dipartimento di Scienze Chimiche e Farmaceutiche

2. Università degli Studi di Trieste

3. 34127 Trieste

4. Italy

5. Molecular Modeling Section (MMS)

6. Dipartimento di Scienze del Farmaco

7. Università di Padova

8. 35131 Padova

9. Institut für Pharmakologie und Toxikologie

10. Universität Würzburg

11. 97078 Würzburg

12. Germany

Abstract

Potent A₃ adenosine receptor antagonists were developed to be conjugated and obtain receptor probes, drug delivery systems, and multitarget or bitopic ligands.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00380H

Reference29 articles.

1. The A3adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches

2. A3Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

3. Identification of A3adenosine receptor agonists as novel non-narcotic analgesics

4. Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

5. The A3 Adenosine Receptor as a New Target for Cancer Therapy and Chemoprotection