1,3-Dipolar cycloaddition of cycloimmonium salts and 4-(trimethylsilyl)-3-butyn-2-one to access new functionalized indolizines with potential cytostatic activity-Reference-Cited by-同舟云学术

1,3-Dipolar cycloaddition of cycloimmonium salts and 4-(trimethylsilyl)-3-butyn-2-one to access new functionalized indolizines with potential cytostatic activity

Published:2023 Issue:8 Volume:47 Page:3758-3772
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Zubaş Andreea¹,Ghinet Alina¹²³^ORCID,Shova Sergiu⁴,Bîcu Elena¹

Affiliation:

1. Alexandru Ioan Cuza’ University of Iasi, Faculty of Chemistry, Bd. Carol I, nr. 11, 700506 Iasi, Romania

2. Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France

3. Univ. Lille, Inserm, CHU Lille, Institut Pasteur Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France

4. Petru Poni’ Institute of Macromolecular Chemistry, Iasi, Romania

Abstract

4-(Trimethylsilyl)-3-butyn-2-one is an effective dipolarophile in the [3+2] cycloaddition reaction with cycloimmonium salts to obtain bioactive non-silicon adducts, namely 1-acetylindolizines, but also trimethylsilyl-containing adducts.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ05257A

Reference27 articles.

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