Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system-Reference-Cited by-同舟云学术

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system

Published:2023 Issue:11 Volume:23 Page:2664-2682
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Barry Antonia¹,Samuel Sabrina F.¹,Hosni Ines¹,Moursi Amr²,Feugere Lauric³,Sennett Christopher J.¹,Deepak Srihari²,Achawal Shailendra²,Rajaraman Chittoor²,Iles Alexander⁴^ORCID,Wollenberg Valero Katharina C.³,Scott Ian S.⁵^ORCID,Green Vicky¹^ORCID,Stead Lucy F.⁶,Greenman John¹^ORCID,Wade Mark A.¹,Beltran-Alvarez Pedro¹^ORCID

Affiliation:

1. Centre for Biomedicine, Hull York Medical School, University of Hull, Hull, UK

2. Department of Neurosurgery, Hull University Teaching Hospitals NHS Trust, Hull Royal Infirmary, Hull, UK

3. Department of Biological and Marine Sciences, University of Hull, Hull, UK

4. Department of Chemistry, University of Hull, Hull, UK

5. Neuroscience Laboratories, The Walton Centre NHS Foundation Trust, Liverpool, UK

6. Leeds Institute of Medical Research at St James's, St James's University Hospital, Leeds, UK

Abstract

Treatment of human brain tumour biopsies, maintained on-chip, with type I PRMT inhibitors leads to apoptosis through changes in gene expression and RNA processing, mediated by cross-talk with type II PRMT.

Funder

University of Hull

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00204G

Reference110 articles.

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4. Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets

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