Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer transcriptomes using a spheroid-on-chip perfusion system-Reference-Cited by-同舟云学术

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer transcriptomes using a spheroid-on-chip perfusion system

Published:2024 Issue: Volume: Page:
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Pyne Emily¹,Reardon Mark²^ORCID,Christensen Martin³,Rodriguez Mateos Pablo⁴,Taylor Scott⁵,Iles Alexander⁴^ORCID,Choudhury Ananya²⁶,Pamme Nicole⁴^ORCID,Pires Isabel M.¹⁵^ORCID

Affiliation:

1. Centre for Biomedicine, HYMS, University of Hull, Hull, UK

2. Translational Radiobiology, Division of Cancer Sciences, University of Manchester, Manchester, UK

3. Department of Chemistry and Biochemistry, University of Hull, Hull, UK

4. Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden

5. Tumour Hypoxia Biology, Division of Cancer Sciences, University of Manchester, Manchester, UK

6. Christie Hospital NHS Foundation Trust, Manchester, UK

Abstract

Spheroid-on-chip model of interstitial fluid flow (IFF) drove dramatic changes in gene expression depending on oxygen conditions and identified potential IFF-associated biomarkers linked with prognostic value in cancer patients.

Funder

Cancer Research UK

Stockholms Universitet

University of Manchester

University of Hull

Biochemical Society

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D4LC00512K

Reference71 articles.

1. Exploring hypoxic biology to improve radiotherapy outcomes

2. Deciphering cell–cell interactions and communication from gene expression

3. Gene Regulation and Cellular Metabolism: An Essential Partnership

4. Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.