Motif-based zwitterionic peptides impact their structure and immunogenicity-Reference-Cited by-同舟云学术

Motif-based zwitterionic peptides impact their structure and immunogenicity

Published:2022 Issue:36 Volume:13 Page:10961-10970
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

McMullen Patrick¹^ORCID,Qiao Qi²,Luozhong Sijin¹,Cai Lirong²,Fang Liang¹,Shao Qing²^ORCID,Jiang Shaoyi¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA

2. Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, 40506, USA

Abstract

Structure breaking amino acids, P, S, and G, are incorporated into low immunogenic unstructured zwitterionic peptide fusion proteins. We find unique sequence motifs that exhibit charge balanced conformations and low immunogenicity.

Funder

University of Kentucky

Cornell University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC03519G

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