A De Novo Strategy To Improve Pharmacokinetics of Proteins from mRNA Therapeutics via Zwitterionic Polypeptide Fusion-Reference-Cited by-同舟云学术

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A De Novo Strategy To Improve Pharmacokinetics of Proteins from mRNA Therapeutics via Zwitterionic Polypeptide Fusion

Published:2024-07-29 Issue:31 Volume:146 Page:21245-21249
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Luozhong Sijin¹^ORCID,Li Ruoxin¹,Tian Zhen²,Cao Zeyu³,Bhashyam Dani¹,Zhang Prince¹,McIlhenny Kay⁴,Fang Liang¹^ORCID,McMullen Patrick¹,Jiang Shaoyi¹^ORCID

Affiliation:

1. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, United States

2. Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, United States

3. Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States

4. Department of Molecular Biology and Genetic, Cornell University, Ithaca, New York 14853, United States

Funder

Cornell University

Division of Materials Research

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c07903

Reference28 articles.

1. Gene therapy comes of age

2. Treatment of Hemophilia A Using Factor VIII Messenger RNA Lipid Nanoparticles

3. Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

4. Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates

5. mRNA in the Context of Protein Replacement Therapy

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