Catch and release strategy of matrix metalloprotease aptamers via thiol–disulfide exchange reaction on a graphene based electrochemical sensor

Author:

Mishyn Vladyslav1,Aslan Merve2,Hugo Adrien1ORCID,Rodrigues Teresa3,Happy Henri1,Sanyal Rana245,Knoll Wolfgang3,Baudoux Florence6,Bouchiat Vincent7,Bilyy Rostyslav O.8ORCID,Boukherroub Rabah1ORCID,Sanyal Amitav24ORCID,Szunerits Sabine1ORCID

Affiliation:

1. Univ. Lille, CNRS, Centrale Lille, Univ. Polytechnique Hauts-de-France, UMR 8520 – IEMN, F-59000 Lille, France

2. Department of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey

3. Department of Scientific Coordination and Management, Danube Private University, A-3500 Krems, Austria

4. Center for Life Sciences and Technologies, Bogazici University, Istanbul, Turkey

5. RS Research, Teknopark Istanbul, Pendik, 34912, Istanbul, Turkey

6. CHU Lille, Service Endocrinologie-Diabétologie-Métabolisme-Nutrition, Pôle Médico-Chirurgical, Hôpital Huriez, 4/5ème étage- Aile Ouest, 59500 Lille, France

7. GRAPHEAL SAS, 25 avenue des Martyres, 38042 Grenoble, CEDEX, France

8. Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine

Abstract

Matrix metalloproteases (MMP) sensing in wound fluids using 1-pyrene pyridyl disulphide modified GFETs in a catch-release approach is discussed.

Funder

Centre National de la Recherche Scientifique

Université de Lille

Agence Nationale de la Recherche

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

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