Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice

Author:

Lu Cong1234ORCID,Gao Rongjing12345,Lv Jingwei67834,Chen Ying910114,Li Shuying1234,Zhang Lijing1234,Zhang Nana1234,Wang Yongquan1234,Fan Bei1234,Liu Xinmin67834,Wang Fengzhong12345

Affiliation:

1. Institute of Food Science and Technology

2. Chinese Academy of Agricultural Sciences (CAAS)

3. Beijing 100193

4. China

5. College of Food Science and Technology

6. Research Center for Pharmacology & Toxicology

7. Institute of Medicinal Plant Development (IMPLAD)

8. Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC)

9. Institute of Chinese Materia Medica

10. China Academy of Chinese Medical Sciences

11. Beijing 100700

Abstract

Chronic ethanol intake can lead to cognitive deficit by reducing cholinergic function, inhibiting synaptic plasticity and causing neuron apoptosis. Soy isoflavones effectively improved the cognitive impairment induced by chronic ethanol exposure.

Funder

China Agricultural Research System

Chinese Academy of Agricultural Sciences

Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences

National Major Science and Technology Projects of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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