A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover-Reference-Cited by-同舟云学术

A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover

Published:2018 Issue:7 Volume:9 Page:1813-1821
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Yajun¹²³⁴,Liu Erkai¹²³⁴,Lam Curtis H.¹²³⁴,Perrin David M.¹²³⁴^ORCID

Affiliation:

1. Chemistry Dept.

2. UBC

3. Vancouver

4. Canada

Abstract

Modified dNTPs permit selection of DNAzymes that cleave RNA targets in the absence of a divalent metal cation (M²⁺) to meet a long-standing goal in bioorganic chemistry.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04491G

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