Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon-Reference-Cited by-同舟云学术

Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Published:2021 Issue:31 Volume:12 Page:10448-10454
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Caiger Lewis¹²³⁴^ORCID,Sinton Conar¹²³⁴^ORCID,Constantin Timothée¹²³⁴^ORCID,Douglas James J.⁵⁶⁴,Sheikh Nadeem S.¹⁷⁸⁹¹⁰,Juliá Fabio¹²³⁴^ORCID,Leonori Daniele¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Manchester

3. Manchester M13 9PL

4. UK

5. Early Chemical Development, Pharmaceuticals Sciences, R&D

6. AstraZeneca

7. College of Science

8. King Faisal University

9. Al-Ahsa 31982

10. Saudi Arabia

Abstract

Halogen-atom transfer (XAT) based on phosphoranyl radical chemistry enables the hydroxymethylation of alkyl iodides with formaldehyde.

Funder

Engineering and Physical Sciences Research Council

H2020 European Research Council

AstraZeneca

Deanship of Scientific Research, King Faisal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03083C

Reference48 articles.

1. Aliphatic C–H Oxidations for Late-Stage Functionalization

2. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

3. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

4. Organic synthesis provides opportunities to transform drug discovery

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