Target identification by image analysis-Reference-Cited by-同舟云学术

Target identification by image analysis

Published:2016 Issue:5 Volume:33 Page:655-667
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Fetz V.¹²³⁴⁵,Prochnow H.¹²³⁴,Brönstrup M.¹²³⁴⁵,Sasse F.¹²³⁴

Affiliation:

1. Helmholtz Centre for Infection Research

2. Department of Chemical Biology

3. D-38124 Braunschweig

4. Germany

5. German Centre for Infection Research (DZIF)

Abstract

Biologically active compounds induce phenotypic changes in target cells, which can be used to predict their modes of action. Such changes were initially detected by a visual inspection of images, while recent studies are based on high content analysis (HCA) methods using automated microscopy and analysis software.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00113G

Reference60 articles.

1. Target deconvolution strategies in drug discovery

2. Natural Products as Chemical Probes

3. How were new medicines discovered?

4. Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

5. Identification of Direct Protein Targets of Small Molecules

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