Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1-Reference-Cited by-同舟云学术

Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1

Published:2016 Issue:5 Volume:33 Page:637-647
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Pham Dianne¹²³⁴,Koide Kazunori¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Pittsburgh

3. Pittsburgh

4. USA

Abstract

The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. They were later found to inhibit the spliceosome.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/NP/C5NP00110B

Reference79 articles.

1. New Antitumor Substances, FR901463, FR901464 and FR901465. II. Activities against Experimental Tumors in Mice and Mechanism of Action.

2. New Antitumor Substances, FR901463, FR901464 and FR901465. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

3. Cytotoxic Spliceostatins fromBurkholderiasp. and Their Semisynthetic Analogues

4. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

5. Total Syntheses, Fragmentation Studies, and Antitumor/Antiproliferative Activities of FR901464 and Its Low Picomolar Analogue

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