It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity-Reference-Cited by-同舟云学术

It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity

Published:2021 Issue:10 Volume:12 Page:1709-1721
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Lima Daisy J. B.¹²^ORCID,Almeida Renata G.³^ORCID,Jardim Guilherme A. M.³⁴^ORCID,Barbosa Breno P. A.²³,Santos Augusto C. C.³^ORCID,Valença Wagner O.³^ORCID,Scheide Marcos R.⁴^ORCID,Gatto Claudia C.⁵^ORCID,de Carvalho Guilherme G. C.¹,Costa Pedro M. S.¹^ORCID,Pessoa Claudia¹^ORCID,Pereira Cynthia L. M.³^ORCID,Jacob Claus²^ORCID,Braga Antonio L.⁴^ORCID,da Silva Júnior Eufrânio N.³^ORCID

Affiliation:

1. Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, 60430-270, Ceará, Brazil

2. Division of Bioorganic Chemistry, School of Pharmacy, University of Saarland, 66123 Saarbruecken, Germany

3. Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil

4. Department of Chemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil

5. Institute of Chemistry, University of Brasilia, Brasilia, 70904-970, DF, Brazil

Abstract

Quinone-based frameworks with antitumor activities were described. We identified compounds with IC50 values below 0.5 μM in cancer cells lines with significantly lower cytotoxicity in the control cell line L929.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Instituto Nacional de Ciência e Tecnologia de Catálise em Sistemas Moleculares e Nanoestruturados

Alexander von Humboldt-Stiftung

Royal Society of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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