Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green, and Efficient Access to Cytotoxic Compounds

Author:

Diogo Emilay B. T.1ORCID,Delolo Fábio G.1ORCID,Graça Gabriela A. P.1ORCID,Paz Esther R. S.1ORCID,Bozzi Ícaro A. O.1ORCID,Diniz Renata1ORCID,Passos Juliano P.1ORCID,Matencio Tulio1ORCID,Soares Liane K.2ORCID,Alves Diego2ORCID,Costa Pedro M. S.3ORCID,Pessoa Claudia3ORCID,Pereira Cynthia L. M.1ORCID,Ackermann Lutz4ORCID,da Silva Júnior Eufrânio N.1ORCID

Affiliation:

1. Instituto de Ciências Exatas Departamento de Química Universidade Federal de Minas Gerais Belo Horizonte MG, 31270-901 Brazil

2. LASOL-CCQFA Universidade Federal de Pelotas UFPel, P.O. Box 354 96010-900 Pelotas Rio Grande do Sul Brazil

3. Department of Physiology and Pharmacology Federal University of Ceará Fortaleza CE, 60430-270 Brazil

4. Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry Georg-August-Universität Göttingen Tammannstrasse 2 37077 Göttingen Germany

Abstract

AbstractUndivided electrochemical cells enable economical preparation of sulphur‐containing naphthoquinones through electrochemical sulphenylation of quinoidal compounds. The environmentally friendly and efficient protocol eliminates the use of chemical oxidants and facilitates the synthesis of the desired molecules. This approach offers an efficient and versatile method to synthesize quinones that exhibit cytotoxicity against cancer cell lines.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

European Research Council

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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