A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil-Reference-Cited by-同舟云学术

A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil

Published:2017 Issue:2 Volume:41 Page:824-829
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Mujahid Mohammad¹²³⁴⁵,Subramanian Jambu¹²³⁴,Nalla Viswanadh¹²³⁴,Sasikumar Murugesan⁶⁷⁸⁹⁴,Kunte Sunita Sharad¹²³⁴,Muthukrishnan Murugan¹²³⁴^ORCID

Affiliation:

1. Organic Chemistry Division

2. CSIR-National Chemical Laboratory

3. Pune-411008

4. India

5. P.G. Department of Chemistry

6. Department of Chemistry

7. School of Basic Sciences

8. Vels University

9. Chennai-600117

Abstract

We report a simple enantioselective synthesis of bepridil enantiomers employing hydrolytic kinetic resolution and the Mitsunobu reaction as key steps.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C6NJ02928K

Reference35 articles.

1. Cellular Action of Calcium Channel Blocking Drugs

2. Calcium channel antagonists, part I: Fundamental properties: Mechanisms. classification, sites of action

3. Electrophysiologic and antiarrhythmic properties of bepridil

4. Bepridil

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