Enantioselective organocatalytic amination of 2-perfluoroalkyl-oxazol-5(2H)-ones towards the synthesis of chiral N,O-aminals with perfluoroalkyl and amino groups
Author:
Affiliation:
1. NMPA Key Laboratory for Research and Evaluation of Innovative Drug
2. Henan Key Laboratory of Organic Functional Molecule and Drug Innovation
3. School of Chemistry and Chemical Engineering
4. Henan Normal University
5. Xinxiang
Abstract
The first highly enantioselective amination at the C-2 position of oxazol-5(2H)-ones has been presented. Two efficient relay asymmetric transformation processes were successfully utilized to synthesize chiral N,O-aminals with a quaternary center.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Henan Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO00569C
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