Asymmetric Brønsted base-catalyzed aza-Michael addition and [3 + 2] cycloaddition reactions of <i>N</i>-ester acylhydrazones and enones-Reference-Cited by-同舟云学术

Asymmetric Brønsted base-catalyzed aza-Michael addition and [3 + 2] cycloaddition reactions of N-ester acylhydrazones and enones

Published:2022 Issue:23 Volume:9 Page:6631-6639
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhu Bo¹^ORCID,Sun Huili¹,Fan Huihui¹,Wang Mengqi¹,Guo Fangyuan¹,Zhai Yubing¹,Zhu Gongming¹,Chang Junbiao¹

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Innovative Drug, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China

Abstract

We reported the first enantioselective Brønsted base-catalyzed aza-Michael addition and stepwise cascade [3+2] cycloaddition between acylhydrazones and unsaturated ketones. The enantio-enriched aza-Michael adducts can be transformed into 2-pyrazolines.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01527G

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1. 6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction

2. New class of potent antitumor acylhydrazone derivatives containing furan