Deformability based sorting of stored red blood cells reveals donor-dependent aging curves-Reference-Cited by-同舟云学术

Deformability based sorting of stored red blood cells reveals donor-dependent aging curves

Published:2020 Issue:2 Volume:20 Page:226-235
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Islamzada Emel¹²³⁴²,Matthews Kerryn⁴²³⁵²,Guo Quan⁵²³,Santoso Aline T.⁴²³⁵²,Duffy Simon P.⁴²³⁵²,Scott Mark D.¹²³⁴²^ORCID,Ma Hongshen¹²³⁴²^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine

2. University of British Columbia

3. Canada

4. Centre for Blood Research

5. Department of Mechanical Engineering

Abstract

Cell sorting using microfluidic ratchets enables sensitive and consistent characterization of donor red blood cell deformability. Using this capability, we show the degradation of red blood cell deformability during cold storage is donor-dependent.

Funder

Canadian Blood Services

Mitacs

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC01058K

Reference73 articles.

1. Progress in Global Blood Safety for HIV

2. Blood and Blood Components: From Similarities to Differences

3. Measurement of Red Cell Lifespan and Aging

4. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c

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