Expeditious assembly of fused dihydropyranones via N-heterocyclic carbene-catalyzed tandem Michael addition/lactonization

Author:

Ren Qiao1234ORCID,Li Muyao1234,Yuan Lujiang1234

Affiliation:

1. College of Pharmaceutical Science

2. Southwest University

3. Chongqing 400715

4. P. R. China

Abstract

A convergent and efficient NHC-catalyzed enantioselective tandem Michael addition/lactonization sequence of ynals with 1,2-dione is disclosed. This strategy expeditiously assembles the valuable optically active fused dihydropyranones in good to high yields and with excellent enantioselectivities.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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