Efficient nickel-catalysed N-alkylation of amines with alcohols

Author:

Afanasenko Anastasiia1234ORCID,Elangovan Saravanakumar1234ORCID,Stuart Marc C. A.12345ORCID,Bonura Giuseppe678ORCID,Frusteri Francesco678,Barta Katalin1234ORCID

Affiliation:

1. Stratingh Institute for Chemistry

2. University of Groningen

3. 9747 AG Groningen

4. The Netherlands

5. Electron Microscopy, Groningen Biomolecular Sciences and Biotechnology Institute

6. CNR-ITAE “Nicola Giordano”

7. 98126 Messina

8. Italy

Abstract

A highly active and easy-to-prepare Ni based catalyst system is presented for the selective N-alkylation of amines with alcohols that is in situ generated from Ni(COD)2 and KOH under ligand-free conditions.

Funder

H2020 European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Reference46 articles.

1. S. A. Lawerence , Amines: Synthesis Properties, and Applications , Cambridge University , 2004

2. A. Ricci , Amino Group Chemistry: From Synthesis to the Life Sciences , Wiley-VCH , Weinheim, Germany , 2008

3. M. B. Smith and J.March , March's Advanced Organic Chemistry , Wiley-Interscience , New York , 2001

4. Sodium borohydride in carboxylic acid media: a phenomenal reduction system

5. P. T. Anastas and J. C.Warner , Green Chemistry: Theory and Practice , Oxford University Press , 1998

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