Nonlinear and vibrational microscopy for label-free characterization of amyloid-β plaques in Alzheimer's disease model

Author:

Cunha Renan12345ORCID,Lafeta Lucas12345ORCID,Fonseca Emerson A.12345ORCID,Barbosa Alexandre12345ORCID,Romano-Silva Marco A.67345ORCID,Vieira Rafael8345ORCID,Jorio Ado12345ORCID,Malard Leandro M.12345ORCID

Affiliation:

1. Departamento de Física

2. ICEx

3. Universidade Federal de Minas Gerais

4. Belo Horizonte

5. Brazil

6. Departamento de Saúde Mental

7. Faculdade de Medicina

8. Departamento de Bioquímica e Imunologia

Abstract

Multimodal optical imaging was used for characterization of amyloid-β plaques in mouse brain tissues. We obtained high-resolution images for different biomarkers and investigated vibrational fingerprints that could be used for diagnostic purposes.

Funder

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Financiadora de Estudos e Projetos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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