SKLB023 hinders renal interstitial fibrosis in obstructive nephropathy by interfering TGF-β1/Smad3 signaling-Reference-Cited by-同舟云学术

SKLB023 hinders renal interstitial fibrosis in obstructive nephropathy by interfering TGF-β1/Smad3 signaling

Published:2018 Issue:11 Volume:8 Page:5891-5896
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Feng Yanhuan¹²³⁴⁵,Xu Jun¹²³⁴⁵^ORCID,Guo Fan¹²³⁴⁵,Huang Rongshuang¹²³⁴⁵,Shi Min¹²³⁴⁵,Li Lingzhi¹²³⁴⁵,Ma Liang¹²³⁴⁵,Fu Ping¹²³⁴⁵^ORCID

Affiliation:

1. Kidney Research Institute

2. Division of Nephrology

3. West China Hospital of Sichuan University

4. Chengdu 610041

5. China

Abstract

The novel small-molecule inhibitor of iNOS (SKLB023) hindered renal interstitial fibrosis in vivo and in vitro by interfering with TGF-β1/Smad3 signaling, highlighting that SKLB023 has potential in the therapeutic strategy for renal fibrosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA00018B

Reference33 articles.

1. Serum creatinine concentration and renal interstitial volume

2. Evidence that fibroblasts derive from epithelium during tissue fibrosis

3. Renal fibrosis: novel insights into mechanisms and therapeutic targets

4. Mechanisms of Tubulointerstitial Fibrosis

5. Renal tubulointerstitial fibrosis: common but never simple

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