Protective effects of SKLB023 on a mouse model of unilateral ureteral obstruction by the modulation of gut microbiota-Reference-Cited by-同舟云学术

Protective effects of SKLB023 on a mouse model of unilateral ureteral obstruction by the modulation of gut microbiota

Published:2018 Issue:70 Volume:8 Page:40232-40242
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Feng Yanhuan¹²³⁴⁵,Li Lingzhi¹²³⁴⁵,Guo Fan¹²³⁴⁵,Li Yanping⁶⁷⁴⁵⁸,Liang Yan⁹⁴⁵⁸,Bai Lin¹⁰¹¹¹²⁴⁵,Ma Liang¹²³⁴⁵^ORCID,Fu Ping¹²³⁴⁵^ORCID

Affiliation:

1. Kidney Research Laboratory

2. Division of Nephrology

3. National Clinical Research Center for Geriatrics

4. West China Hospital of Sichuan University

5. Chengdu 610041

6. Laboratory of Clinical Pharmacy and Adverse Drug Reaction

7. Department of Pharmacy

8. China

9. Core Facility of West China Hospital

10. Key Laboratory of Transplant Engineering and Immunology

11. Ministry of Health

12. Regenerative Medicine Research Center

Abstract

Renal fibrosis is the common pathway underlying the progression of CKD to ESRD and quantitative and qualitative alterations in gut microbiota are noted in patients with CKD. Our results indicated SKLB023 drives the alteration of gut microbiota to attenuate renal fibrosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA08049F

Reference68 articles.

1. Commensal Host-Bacterial Relationships in the Gut

2. Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

3. Human Microbiome in Health and Disease

4. Human gut microbes associated with obesity

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