Enantio-conversion and -selectivity of racemic atenolol kinetic resolution using free Pseudomonas fluorescens lipase (Amano) conducted via transesterification reaction

Author:

Agustian Joni12345,Kamaruddin Azlina Harun6789,Aboul-Enein Hassan Y.10111213

Affiliation:

1. Department of Chemical Engineering

2. Faculty of Engineering

3. Universitas Lampung

4. Bandar Lampung 35145

5. Indonesia

6. School of Chemical Engineering

7. Universiti Sains Malaysia

8. Penang

9. Malaysia

10. Pharmaceutical and Medicinal Chemistry Department

11. National Research Centre

12. Cairo

13. Egypt

Abstract

Effects of reaction parameters on kinetic resolution of racemic atenolol usingPseudomonas fluorescenslipase were investigatedviatransesterification for production of pharmacologically active eutomer (S)-atenolol with high enantiomeric purity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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