Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles-Reference-Cited by-同舟云学术

Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

Published:2021 Issue:11 Volume:21 Page:2178-2193
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Erfle Peer¹²³⁴¹^ORCID,Riewe Juliane¹⁵⁶⁴¹^ORCID,Bunjes Heike¹⁵⁶⁴¹^ORCID,Dietzel Andreas¹²³⁴¹^ORCID

Affiliation:

1. Technische Universität Braunschweig

2. Institut für Mikrotechnik

3. 38124 Braunschweig

4. Germany

5. Zentrum für Pharmaverfahrenstechnik (PVZ)

6. 38106 Braunschweig

Abstract

Coaxial flow injection and mixing of solvent and antisolvent flows prevent contact of the lipid solution with microchannel walls and enable stable continuous precipitation of monodisperse nanoparticles in the order of 150 nm and below.

Funder

Boehringer Ingelheim

Niedersächsisches Ministerium für Wissenschaft und Kultur

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00047K

Reference59 articles.

1. Strategies to Address Low Drug Solubility in Discovery and Development

2. Novel strategies for the formulation and processing of poorly water-soluble drugs