Pretargeted imaging beyond the blood–brain barrier-Reference-Cited by-同舟云学术

Pretargeted imaging beyond the blood–brain barrier

Published:2023 Issue:3 Volume:14 Page:444-453
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Shalgunov Vladimir¹^ORCID,Lopes van den Broek Sara¹^ORCID,Vang Andersen Ida¹^ORCID,García Vázquez Rocío¹,Raval Nakul Ravi²³,Palner Mikael²⁴^ORCID,Mori Yuki⁴^ORCID,Schäfer Gabriela⁵,Herrmann Barbara⁶,Mikula Hannes⁶^ORCID,Beschorner Natalie⁴,Nedergaard Maiken⁴,Syvänen Stina⁷^ORCID,Barz Matthias⁴⁸,Moos Knudsen Gitte²⁹,Battisti Umberto Maria¹^ORCID,Herth Matthias Manfred¹¹⁰^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

2. Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, Rigshospitalet Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

3. Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

4. Center for Translational Neuromedicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

5. Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands

6. Institute of Applied Synthetic Chemistry, Technische Universitat Wien (TU Wien), Getreidemarkt 9, 1060 Vienna, Austria

7. Rudbeck Laboratory, Department of Public Health and Caring Sciences, Uppsala University, Dag Hammarskjölds Väg 20, 75185 Uppsala, Sweden

8. Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany

9. Department of Clinical Medicine, University of Copenhagen, Denmark

10. Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark

Abstract

By screening a library of 18F-labeled tetrazines, we identified tetrazines which showed high pretargeted PET imaging contrast beyond the blood–brain-barrier.

Funder

Horizon 2020 Framework Programme

Danmarks Frie Forskningsfond

Novo Nordisk Fonden

Lundbeckfonden

Innovationsfonden

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00360K

Reference65 articles.

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