Legumain-mediated self-assembly of a <sup>131</sup>I-labelled agent for targeted radiotherapy of tumors-Reference-Cited by-同舟云学术

Legumain-mediated self-assembly of a ¹³¹I-labelled agent for targeted radiotherapy of tumors

Published:2022 Issue:13 Volume:10 Page:2251-2259
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Wang Qiqi¹²³,Lu Chunmei²³,Li Ke³,Xia Yongmei¹²^ORCID,Qiu Ling³^ORCID,Lin Jianguo³^ORCID

Affiliation:

1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China

2. School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

3. NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, P. R. China

Abstract

A novel radiopharmaceutical [131I]MAAN could be specifically cleaved by legumain and reduced by GSH to form nanoaggregates for enhancing the imaging signal and targeted radiotherapy efficacy of tumors.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Wuxi Municipal Bureau on Science and Technology

Jiangsu Provincial Commission of Health and Family Planning

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D1TB02862F

Reference36 articles.