Identification of the first structurally validated covalent ligands of the small GTPase RAB27A-Reference-Cited by-同舟云学术

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A

Published:2022 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Jamshidiha Mostafa¹²,Lanyon-Hogg Thomas¹²^ORCID,Sutherell Charlotte L.²,Craven Gregory B.¹,Tersa Montse¹,De Vita Elena²^ORCID,Brustur Delia²,Pérez-Dorado Inmaculada¹,Hassan Sarah²^ORCID,Petracca Rita²,Morgan Rhodri M.¹,Sanz-Hernández Máximo¹,Norman Jim C.³,Armstrong Alan²^ORCID,Mann David J.¹,Cota Ernesto¹,Tate Edward W.²^ORCID

Affiliation:

1. Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK

2. Department of Chemistry, Imperial College London, London, W12 0BZ, UK

3. Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK

Abstract

A novel Rab27A construct enables elucidation of covalent ligand binding, paving the way for structure-guided approaches against this challenging target.

Funder

European Commission

Imperial College London

Cancer Research UK

Biotechnology and Biological Sciences Research Council

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D1MD00225B