Bifunctional aryloxyphosphoramidate prodrugs of 2′-C-Me-uridine: synthesis and anti-HCV activity-Reference-Cited by-同舟云学术

Bifunctional aryloxyphosphoramidate prodrugs of 2′-C-Me-uridine: synthesis and anti-HCV activity

Published:2016 Issue:37 Volume:14 Page:8743-8757
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Maiti Munmun¹²³⁴⁵,Gao Ling-Jie¹²³⁴⁵,Huang Chunsheng⁶⁷⁸⁹,Ptak Roger G.⁶⁷⁸⁹,Murray Michael G.⁶⁷⁸⁹,De Jonghe Steven¹²³⁴⁵,Herdewijn Piet¹²³⁴⁵

Affiliation:

1. KU Leuven

2. Rega Institute

3. Laboratory of Medicinal Chemistry

4. 3000 Leuven

5. Belgium

6. Southern Research

7. Infectious Disease Research

8. Frederick

9. USA

Abstract

A series of l-glutamic acid, l-serine, l-threonine and l-tyrosine containing aryloxyphosphoramidate prodrugs of 2′-C-Me-uridine displayed very potent activity against HCV.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01189F

Reference15 articles.

1. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

2. Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs

3. Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

4. Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

5. Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus

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