Target-activated transcription for the amplified sensing of protease biomarkers

Author:

Liu Fang12345,Yang Min12345,Song Wenlu12345,Luo Xingyu12345,Tang Rui12345,Duan Zhixi678910,Kang Wenyuan12345,Xie Shiyi12345,Liu Qingqing12345,Lei Chunyang12345,Huang Yan12345ORCID,Nie Zhou12345ORCID,Yao Shouzhuo12345

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics

2. College of Chemistry and Chemical Engineering

3. Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology

4. Hunan University

5. Changsha 410082

6. Department of Orthopedics

7. The Second Xiangya Hospital

8. Central South University

9. Changsha 410011

10. P. R. China

Abstract

A transcription-inspired signal amplification strategy that amplifies proteolysis into nucleic acid outputs is presented for the ultrasensitive sensing of protease biomarkers.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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